Microparticle Detection and its Clinical Application

Invitrox has 5 U.S. issued patents available for license or purchase focused on Microparticle Detection

The microparticles (microvesicles) / cell fragments generated in the bloodstream after cell activation, mechanical shear or death mimic the metabolic state of the cell. Some tumor cells generate microparticles (MPs) constitutively. Accurate detection and identification of the number and phenotype of these microparticles can provide early evidence of cell damage or presence of cancer and is useful for clinical diagnostic procedures and therapeutic monitoring.

ISADE: Invitrox Surface Antigen Detection Enumerator

ISADE is a custom built light-scattering device with microparticle detection and analysis capabilities. By using a small blood sample ISADE is able to rapidly determine;

  • Number
  • Size
  • Phenotype
  • Origin

ISADE offers unprecedented resolution and accurate detection of previously undetectable microparticles. After detecting microparticles, ISADE can phenotype cells using antibodies. ISADE’s assays have applications for;

  • Disease detection
  • Drug discovery
  • Drug development and monitoring
  • Research

Clinical Application Highlight

In myocardial infarction, creatine phosphokinase and troponin levels are elevated after myocardial damage has occurred. ISADE can detect these elevated levels of microparticles along with counting and phenotyping them. ISADE’s unrivaled diagnostic capabilities allow early and potentially life-saving interventions for this and other conditions including:

• Stroke
• Pulmonary hypertension
• Coronary artery disease
• Acute liver failure

• Cancer
• Metabolic syndrome
• End-stage renal failure
• Sepsis

Details and Links to our U.S. Patents:

1. Use of Focused Light Scattering Techniques in Biological Applications



2. Use of Focused Light Scattering Techniques in Biological Applications



3. Instrument and Method for Optical Particle Sensing



4. Methods for Determining Patient Response to Anti-Platelet Aggregation Therapy



5. Use of Focused Light Scattering Techniques in Biological Applications




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