Platelet Function Testing
Why are Platelet Function Tests Performed?
Identify and diagnose platelet dysfunction:
Platelet aggregometry has utility in diagnosis of inherited and acquired platelet dysfunction disorders. Platelet dysfunction disorders may take on many forms and levels of severity, ranging from someone with occasional nosebleeds, heavy menstrual bleeding, to those who experience frequent excessive bleeding during medical procedures and/or daily life activities. Identification of platelet dysfunction and the development of a treatment path forward are critical to the longevity and well-being of those who suffer from platelet dysfunction.
Monitor anti-platelet therapy:
Anti-platelet therapy is routinely administered to patients after a stroke or heart attack to help inhibit blood clotting. Currently, most anti-platelet therapies cannot be routinely monitored with platelet function testing. REACT-P is a CLIA validated test service offering provided by Invitrox, Inc. for evaluation of platelet activation to assess the appropriateness of drug treatments involving anti-platelet therapy.
If platelets fail to activate when challenged with the appropriate platelet agonist, it indicates that the antiplatelet drug is effective.
If platelets activate when challenged, it indicates that the antiplatelet drug is ineffective.
Screen at-risk pre-surgical patients:
Pre-surgery screening is routinely performed as part of a patient risk assessment prior to surgical procedures. For patients with potential cardiac or hematological risks, REACT-P is able to determine the likelihood of excessive bleeding during an invasive procedure, providing patients with piece of mind as REACT-P can detect abnormalities in platelet function before it is too late. Doctors currently evaluate a patient for known risk factors and rely on a patient’s clinical history and secondary haemostasis (PT and aPTT) to determine their overall risk of excessive bleeding. However, prior to REACT-P, there has been no consistently reliable platelet function screening test to predict which patients are likely to bleed during surgery or experience other cardiac and/or hematological issues.